AZACITIDINE PACKAGE INSERT PDF

MyAza (Azacitidine for Injection) contains Azacitidine IP, which is a pyrimidine The finished product is supplied in a sterile form for reconstitution as a. No formal clinical drug interaction studies with azacitidine have been conducted. The printed package leaflet of the medicinal product must state the name. Drug: Azacitidine – Vidaza® Oncology – Intravenous Dilution Data. (, ) – [ SEE PACKAGE INSERT FOR ADDITIONAL DETAILS]].

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Doses greater than 4 mL should be divided equally into 2 syringes. Rotate sites for each injection thigh, abdomen, or upper arm. Significant hematologic toxicity was noted with no response as defined by bone marrow remission or improvement in transfusion requirements.

Your Name Your name is required. The potential of azacitidine to inhibit cytochrome P CYP enzymes is not known. Mannitol-containing and mannitol-free formulations have different stability following reconstitution for subcutaneous use.

Azacitidine – Drug Information – Chemocare

Azacitidine is an anti-cancer “antineoplastic” or “cytotoxic” chemotherapy drug. If the dose requires azaccitidine more than one mg vial, divide the dose equally between 2 syringes; due to retention in the vial and needle, it may not be feasible to withdraw all of the contents from the vial.

Azacitidine is contraindicated in patients with advanced hepatic malignancies. Shake or roll the vial vigorously until a uniform suspension occurs; the suspension will be cloudy. However, you should always inform your health care provider if you experience any unusual symptoms.

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Azacitidine is a member of a new class of drugs known as DNA “demethylating” agents. Not all side effects are listed above. A dosage adjustment in subsequent cycles may be required based on nadir counts and hematologic response.

Affected cytochrome P isoenzymes or drug transporters: This suppressed reactivity can persist for up to 6 weeks after treatment discontinuation. Bone marrow suppression, neutropenia, thrombocytopenia.

Among those patients, overall survival was Under refrigeration 2 to 8 degrees C or 36 to 46 degrees Fthe solution in the vial or a syringe is stable for up to 8 hours when reconstituted with Sterile Water for injection that was not refrigerated or for up to 22 hours when reconstituted with Sterile Water for injection that was refrigerated. When there is an increase in DNA methylation this can result in the blockage of the activity of “suppressor genes” that regulate cell division and growth.

Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.

Azacitidine is contraindicated in patients with mannitol hypersensitivity or sensitivity to azacitidine. Give new injections at least one inch from an old site; do not inject in a site that is tender, bruised, red, or hard.

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Controlling Occupational Exposure to Hazardous Drugs.

Vidaza (azacitidine) dose, indications, adverse effects, interactions from

Counsel patients about the reproductive risk and contraception requirements azacitidien azacitidine treatment. Am J Health-Syst Pharm. Women who become pregnant while receiving azacitidine should be apprised of the potential hazard to the fetus.

Azacitidine’s anticancer effects are believed to be twofold. Azacitidine is a pyrimidine analog for cytosine.

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Send the page ” ” to a friend, relative, colleague or yourself. Chemotherapy and biotherapy guidelines and recommendations for practice 2nd. QOL assessment found significant major advantages in physical function, symptoms, and psychological state for patients initially treated with azacitidine. Non-proliferating cells are relatively insensitive to azacitidine.

It is recommended that patients be treated for a minimum of 4 to 6 cycles. An in vitro study indicated that it may be metabolized by the liver. Hypomethylation may restore normal gene function to those genes critical for differentiation and proliferation. Hypomethylation may restore normal function to genes that are azaditidine for differentiation and proliferation. Methylation usually suppresses gene transcription and gene deletion.