APIDRA PACKAGE INSERT PDF

Apidra SoloStar Units/ml solution for injection in a pre-filled pen – Patient The Patient Information Leaflet (PIL) is the leaflet included in the pack with a. Apidra SoloStar Units/ml solution for injection in a pre-filled pen . SoloStar, the Instructions for use included in the Package leaflet must be read carefully. APIDRA [insulin glulisine injection (rDNA origin)] is a recombinant . package insert, and the pump manufacturer’s manual (see DOSAGE AND.

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Exenatide may be used with basal insulin regimens.

Apidra SoloStar 100 Units/ml solution for injection in a pre-filled pen

Insulin glulisine contains m-cresol and should be avoided in patients with m-cresol hypersensitivity; localized reactions and general myalgias have been paxkage with the use of cresol as an injectable excipient. Moderate Tacrolimus has been reported to cause hyperglycemia. Moderate The risk of hypoglycemia is increased when lixisenatide is used in combination with insulin glulisine.

Contents of the pack and other information. If you need a dose greater than 80 units, you should give it as two or more injections. Patients with diabetes treated with pegvisomant and antidiabetic agents may be more likely to experience hypoglycemia.

When used for intermittent subcutaneous injection, the total daily dose is apiera as 2 to 4 subcutaneous injections, within 15 minutes before or 20 minutes after starting a meal to avoid hypoglycemia.

Insulin glulisine is equipotent to regular inserh, but with more rapid activity and a shorter duration of action when given via intermittent subcutaneous injection. Associated symptoms may include large-scale skin reactions rash and itching all over the bodysevere swelling of skin or mucous membranes angiooedemashortness of breath, a fall in blood pressure inserrt rapid heart beat and sweating.

Change the infusion sets and the insulin glulisine in the external insulin reservoir every 48 hours as insulin degradation and loss of m-cresol have been demonstrated after this time. Do not throw away any medicines via inwert or household waste. Test your blood sugar level and lackage urine apidrz ketones as soon as any of the above symptoms occur. Many geriatric patients suffer from visual impairment, and patients with visual impairment may rely on audible clicks from insulin pens to dial their dose; preparing the injection by using audible clicks may result in dosing errors.

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For more information on signs and symptoms of hyperglycaemia refer to the box at the end of this leaflet. To bookmark a medicine you must sign up and log in. Make sure that the tip of the needle does not touch the NPH insulin. Titrate dosage according to blood glucose and A1C goals.

Insulin glulisine in an external pump reservoir should be discarded after 48 hours of use. It is a clear, colourless, aqueous solution with no particles visible. The hypoglycemic effect induced by IGF-1 activity may be exacerbated. Inform your doctor as soon as possible if you experience signs of heart failure such as unusual shortness of breath or rapid increase in weight or localised swelling oedema.

Most experts, including the American College of Obstetrics and Gynecologists ACOG and the American Diabetes Association ADArecommend human insulin as the therapy of choice to maintain blood glucose as close to normal as possible during pregnancy in patients with Type 1 or 2 diabetes mellitus, and, if diet therapy alone is not successful, for those patients with gestational diabetes; insulin does not cross the placenta. Insulin glulisine and NPH insulin should be mixed immediately before injection.

Patients should be closely monitored while receiving bexarotene capsules in combination with insulin therapy; monitor for hypoglycemia and need for diabetic therapy adjustments. Of note, lorcaserin has not been studied in combination with insulin. Clean the rubber stopper of both vials of insulin with an alcohol wipe.

To prepare a dose from a vial: The pen plunger moves with each dose. Your email has been sent.

You can also report side effects directly via the Yellow Card Scheme at: Infusion bags prepared with normal saline as outlined above are stable for 48 hours after preparation. The volume of distribution of insulin paclage after IV administration is 13 L, which is similar to the volume of distribution of regular insulin after IV administration 21 L.

Although pharmacokinetic data are available and the drug has been used as an intravenous infusion in healthy subjects, dosage information for the treatment of hyperglycemia is not available.

Minor Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. Moderate Monitor patients receiving insulin closely for worsening glycemic control when corticosteroids are instituted and for signs inseert hypoglycemia when corticosteroids are discontinued.

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For the safety pen needle, remove only the outer cover; the fixed inner needle shield remains in place. Hepatic disease, renal impairment, or renal failure may affect dosage requirements of insulin like insulin glulisine.

Fast-Acting, Mealtime Insulin | Apidra® (insulin glulisine [rDNA origin] injection)

Read carefully all of this leaflet including the Instructions for Use of Apidra SoloStar, pre-filled pen, before using this medicine because it contains important pacckage for you. Children or thin individuals can use a short needle and a 45 degree angle to avoid intramuscular injection.

Always put the pen cap back on the pen, then store the pen until your next injection. Send the page ” ” to a friend, relative, colleague or yourself. Changing the injection site with each injection may help to prevent such skin changes. Use of exogenous insulin may impact the accuracy of the macimorelin growth hormone test by directly affecting pituitary growth hormone secretion and by transiently elevating growth hormone concentrations.

Important information about some of the ingredients of Apidra This medicine contains less than 1 mmol 23 mg sodium per dose, i. Apidra can be injected in the abdominal wall, the thigh or upper arm or by continuous infusion in the abdominal wall. Diabetic patients receiving calcium EDTA may require adjustments in their insulin dosage. Some patients may require adjustment to their hypoglycemic medications over time. If your SoloStar is in cool storage, take it out 1 to 2 hours before you inject to allow it to warm up to room temperature.

Only use it if the solution is clear, colourless and has no visible particles in it. This ensures that you get an accurate dose by: Check the appearance of your insulin.

Major Pramlintide is indicated to be used in combination with insulins; however, pramlintide increases the risk of insulin-induced hypoglycemia.