1. Eur Ann Otorhinolaryngol Head Neck Dis. Feb;(1) doi: / Epub Jul 9. A case of an ameloblastic fibrosarcoma in the mandible is described. The primary tumor was seen in a 5-year-old child. In spite of repeated surgical. Introduction. Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. It can arise de novo, however one-third of cases may arise from a recurrent.

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Clinico-pathologic, histoenzymological and ultrastructural study. In a few described cases, adjuvant chemotherapy was used, with inconclusive results 4. Radical surgical excision and long-term follow-up are the suggested treatment. Report of 2 chemosensitive pediatric cases. Panoramic radiograph a and axial CT scan b revealing an ill-defined radiolucent lesion around an impacted mandibular left first molar. Ameloblastic fibroodontoma of the mandible with normal karyotype in a pediatric patient.

It is regarded as the malignant counterpart of ameloblastic fibroma AF. One case was diagnosed as de novo and the other was diagnosed as malignant transformation of a previous AF. Ameloblastic sarcoma in the maxilla.

There were regional and distant metastases reported in less than Ameloblastic fibroma and related lesions: Radiographically, AFS usually appears as an expansile destructive radiolucency with ill-defined margins.

For the authors, segregation of these lesions based on their mesenchymal inductive potentials seems to be inappropriate.

Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up

En bloc surgical resection from the second premolar to the anterior ramus region was performed under general anesthesia. Adamantinosarcoma of the maxilla. He performed an incisional biopsy and sent it to a general pathology service for histopathologic examination. Panoramic radiographs demonstrated an ill-defined unilocular radiolucent lesion in the left posterior region of maxilla and the left maxillary sinus was totally obliterated.


AFS is a locally aggressive malignant tumor, with regional and distant metastases being uncommon. The patients received initial aggressive surgical management. An incisional biopsy was performed, followed by routine histopathology, resulting in the diagnosis of primary AFS.

Ameloblastic fibrosarcoma: a rare malignant odontogenic tumor.

Left half of mandible. Swelling was present in all cases and pain was the chief complaint in six of eight Although cell proliferation is up-regulated in the fibrowarcoma component, it does not appear to affect the differentiation status of the ameloblastic epithelium in AFS. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions.

Those lesions arising from an AF tend to occur in patients aged approximately a decade older than those arising de novo [ 10 ]. Ameloblastic fibroma or ameloblastic fibrosarcoma. Radiographic examination showed an extensive ill-defined unilocular radiolucent lesion around an impacted mandibular left first molar. Other important regulatory cell cycle proteins are p63 and p Ameloblastic fibrosarcoma [title] mandible. Stromal components amelobpastic hyperchromatic and pleomorphic cells, as well as numerous mitotic structures Fig.

A year-old female presented with a 2-month history of an asymptomatic swelling in her left mandible. Since then, there amelpblastic about cases of similar microarchitectural features described in the literature.

Ameloblastic fibrosarcoma of the mandible: Histopathological examination of the resected specimen showed evidence of scant cords and nests of odontogenic epithelium scattered within the mesenchymal stromal tissue Fig.

For Ki analysis, the mean number of positive cell ameloblawtic in 10 consecutive high-power fields HPFs was determined. There was some suggestive morphological and behavioral evidence of similarities among these lesions.

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Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

Odontogenic tumors and tumor-like lesions constitute a rare group of heterogeneous diseases that range from nonneoplastic tissue proliferations to malignant tumors with metastatic potential.

In Brazilian series, the reported frequency of AFS is up to 1.

Oral mucosa and mandibular nerve functions were normal and intact. Five cases of tumor of jaws treated by excision. CD34 expressing ameloblastic fibrosarcoma arising in the maxilla: Abstract Ameloblastic fibrosarcoma AFS is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma. Ameloblastic fibrosarcoma AFS is a rare malignant odontogenic tumor.

Pathology Research and Practice. Beitrage zur Lehre von den Adamantinomen. Transformation of ameloblastic fibroma to fibrosarcoma. Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life.

Epithelial dysplasia in ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma in a year-old Iranian man. Computed tomography scan shows extensive destruction of the left maxillary sinus.

Microscopic examination of the slides revealed a neoplastic tissue with scattered benign appearing cords and nests of epithelial cuboidal or columnar cells with peripheral palisading in a myxoid to highly cellular mesenchymal background mostly composed of plump stellate and ovoid to spindle cells.

Footnotes Source of Support: Brit M J ;1: Pathology and Genetics of Head and Neck Tumours.